dacotin-100

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Product Description (500 words)

Dacotin-100 is an injectable chemotherapy drug containing Oxaliplatin 100 mg, a platinum-based compound used primarily to treat advanced colorectal cancer (colon and rectal cancers). It is often given in combination with other chemotherapeutic agents like 5-fluorouracil (5-FU) and leucovorin in regimens such as FOLFOX.

Oxaliplatin works by binding to DNA in cancer cells, disrupting their replication and leading to cell death. It is a key part of first-line or second-line treatment for patients with metastatic colorectal cancer and is sometimes used after surgical resection of tumors to reduce recurrence risk.

Dacotin-100 is administered as an intravenous (IV) infusion under the supervision of a qualified oncologist in a hospital or cancer center. Treatment schedules typically involve cycles every 2–3 weeks, depending on the treatment protocol and patient tolerance.

Uses of Dacotin-100

✅ Advanced Colorectal Cancer — first-line or second-line chemotherapy in combination with other agents
✅ Adjuvant Therapy — following surgical removal of colon cancer to reduce the risk of recurrence
✅ Other Solid Tumors (investigational use) — under clinical guidance, sometimes explored in combination regimens for other cancers

Key Benefits

• Effective against advanced cancers: Helps control tumor growth and spread in colorectal cancer.

• Synergistic in combinations: Works well with 5-FU and leucovorin, improving treatment outcomes.

• Platinum-based strength: Offers a distinct mechanism compared to non-platinum chemotherapies.

• Proven survival benefit: Shown to improve progression-free and overall survival in clinical trials.

How Dacotin Works

Oxaliplatin, the active ingredient in Dacotin-100, belongs to the platinum-based class of chemotherapeutic agents. It forms platinum-DNA adducts that prevent DNA replication and transcription, ultimately leading to apoptosis (programmed cell death) in cancer cells.

When combined with other chemotherapy agents like 5-FU and leucovorin, oxaliplatin enhances the cytotoxic effect, making it a central component in colorectal cancer treatment regimens.

Dosage & Administration

• Standard dose: 85 mg/m² every 2 weeks as part of the FOLFOX regimen; Dacotin-100 provides 100 mg per vial for preparation.

• Route of administration: Intravenous infusion over 2–6 hours, depending on combination drugs used.

• Number of cycles: Usually continued until disease progression or unacceptable toxicity, often up to 12 cycles.

• Pre-medication: Antiemetics and hydration are often given to reduce nausea and kidney side effects.