Doriglen 500 mg

Doriglen 500 mg is an injectable antibiotic containing Doripenem, a broad-spectrum carbapenem antibiotic used to treat severe and complicated bacterial infections. It is highly effective against a wide range of Gram-positive and Gram-negative bacteria, including drug-resistant strains, making it an essential option in hospitals for treating life-threatening infections.

Doripenem works by inhibiting bacterial cell wall synthesis, leading to the destruction of bacteria. It is commonly used in the management of complicated intra-abdominal infections, complicated urinary tract infections (including pyelonephritis), and hospital-acquired bacterial pneumonia (HABP), including ventilator-associated bacterial pneumonia (VABP).

Doriglen is administered by intravenous (IV) infusion in a hospital setting under the supervision of healthcare professionals. The choice of this antibiotic is typically reserved for serious infections where other treatments may not be effective, especially in critically ill patients.

Uses of Doriglen 500 mg

✅ Complicated Intra-abdominal Infections — infections inside the abdomen that are resistant to simpler antibiotics
✅ Complicated Urinary Tract Infections (UTIs) — including kidney infections (pyelonephritis) caused by resistant bacteria
✅ Hospital-Acquired Pneumonia (HAP) & Ventilator-Associated Pneumonia (VAP) — severe lung infections acquired in hospital settings
✅ Severe Bacterial Infections in Critically Ill Patients — where broad-spectrum, potent antibiotics are required

Key Benefits

• Broad-spectrum coverage: Effective against a wide range of Gram-positive and Gram-negative bacteria, including resistant strains.

• High efficacy: Designed for severe infections where other antibiotics may fail.

• Rapid action: Quickly penetrates infection sites and achieves therapeutic levels in body fluids and tissues.

• Hospital-strength antibiotic: Intended for use in critical and life-threatening infections.

How Doriglen Works

Doripenem, the active ingredient in Doriglen, belongs to the carbapenem class of beta-lactam antibiotics. It exerts its action by binding to penicillin-binding proteins (PBPs) in bacteria, inhibiting cell wall synthesis, and causing bacterial cell death.

Because of its potent action and broad coverage, Doriglen is often used as a last-line antibiotic in hospitals to combat serious infections, including those caused by multi-drug-resistant organisms.

Dosage & Administration

• Standard dose: 500 mg every 8 hours, administered by intravenous infusion over 1 hour.

• Duration of treatment: Typically ranges from 5 to 14 days, depending on the severity and type of infection.

• Renal impairment: Dosage adjustments are required in patients with reduced kidney function.

• Hospital use only: Doriglen should only be administered under strict medical supervision by trained healthcare personnel.