Tegonat 20 capsules

Tegonat Tablets

Product Description:

Tegonat is a fixed-dose combination of Tegafur, Gimeracil, and Oteracil, developed to treat advanced gastric cancer and metastatic colorectal cancer. This oral chemotherapy regimen is bioequivalent to Teysuno® (S-1) and works by enhancing the anti-cancer activity of 5-fluorouracil (5-FU) while reducing its gastrointestinal side effects.

Tegonat is formulated to maximize anti-tumor efficacy and minimize toxicity by combining:

• Tegafur: A prodrug of 5-FU (cytotoxic agent)

• Gimeracil: A dihydropyrimidine dehydrogenase (DPD) inhibitor that increases 5-FU bioavailability

• Oteracil: Reduces gastrointestinal side effects by blocking 5-FU phosphorylation in the gut

Indications:

• Advanced gastric (stomach) cancer, in combination with cisplatin

• Metastatic colorectal cancer in patients unable to tolerate standard fluoropyrimidine therapies

• May be considered for other solid tumors as determined by oncology specialists

Mechanism of Action:

Tegonat acts through modulation of 5-FU metabolism. Tegafur converts to 5-FU in the body, Gimeracil inhibits the breakdown of 5-FU to prolong its action, and Oteracil selectively reduces GI toxicity, offering a balanced and tolerable chemotherapy regimen.

Key Features:

• Oral fluoropyrimidine therapy with improved tolerability

• Equivalent to Teysuno® / TS-One used widely in Japan and Europe

• Convenient oral administration, reducing the need for IV infusions